Heart has a limited potential to synthesize fatty acid (FA) and therefore FA is supplied from several sources: lipolysis of endogenous cardiac triglyceride (TG) stores, or from exogenous sources in the blood. Lipoprotein lipase (LPL), synthesized in cardiomyocytes, catalyzes the breakdown of the TG component of lipoproteins to provide FA to the heart. It is the vascular endothelial-bound LPL that determines the rate of plasma TG clearance and hence, it is also called heparin releasable (HR) "functional" LPL. Functional LPL is regulated by numerous dietary and hormonal factors, and is sensitive to pathophysiological alterations like those observed during diabetes. In this condition, absolute or relative lack of insulin impairs cardiac glucose transport and oxidation, resulting in FA becoming the preferred means of energy supply. To make available this increased requirement of the heart for FA, diabetic heart upregulates its luminal LPL activity by posttranslational mechanisms. Chronically elevated cardiac LPL can result in abnormal FA supply and utilization by the heart tissue that could potentially initiate and sustain cardiac dysfunction during diabetes.
We are?seeking an active?individual who can join our laboratory as a PhD Student working on the regulation of cardiac LPL in an attempt to piece together how early metabolic changes could instigate diabetic heart disease. More research information could be found on our website (http://www.pharmacy.ubc.ca/research/researchers/brian-rodrigues). We anticipate a start date of January 1, 2013. Personnel specifications of the candidate include:
??????????? A Masters degree
??????????? Interest in Biological Research
??????????? Excellent organizational ability and strong communication skills
??????????? Experience in cell isolation, cell culture, Western Blotting, rtPCR and enzymology
Interested individuals are requested to submit an application and current CV to:
Rachel Wu, Graduate Programs Manager; Faculty of Pharmaceutical Sciences; The University of British Columbia; 371E-2146 East Mall, Vancouver, BC, Canada V6T 1Z3; Tel:604-827-0188; 604-827-0188.? Email: rawu@mail.ubc.ca
Application Deadline : 31 October 2012
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Contact Adress: Rachel Wu
Contact Email: rawu@mail.ubc.ca
Posted on 2012-10-12 18:17:17
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